Nancy Friedman blogged in October 2006 about
Word of the Week: Pizzled
Pizzled: A combination of "puzzled" and "pissed off." Coined by psychiatrist Edward Hallowell in his book CrazyBusy: Overstretched, Overbooked, and About to Snap! Strategies for Coping in a World Gone ADD (whew!) to describe how you feel "when you're eating with somebody and their phone rings and they answer it." Evidently he hadn't researched the traditional meaning of "pizzle," which has been around since 1523.